Generally it is safe.

Glucosamine is a nutraceutical product that has gained a lot of popularity. This compound is available in many forms, some of which are specifically designed for veterinary use. Primarily, glucosamine and chondroitin sulfate are used to help diminish the symptoms associated with osteoarthritis, which is the "wear and tear" type of arthritis. Although the usefulness of purified glycosaminoglycan has been documented, the efficacy of the oral combination product of glucosamine and chondroitin sulfate is in dispute. Additionally, the formulations for these products are not standardized, making them even more difficult to evaluate. The chondroitin portion of the supplement increases the elasticity of cartilage and may have anti-inflammatory properties. Both glucosamine and chondroitin are required for proteoglycan synthesis. These compounds assist in the joint's recovery from the constant trauma of the osteoarthritis. Theoretically, they are given as a source of cartilage matrix precursors and to stimulate regeneration. Unfortunately, the exact mechanism of action is poorly understood. Controlled studies for the effectiveness of these compounds are lacking. In general, these products are safe and have only a minimal chance of producing toxicity or allergic reactions. Minor gastrointestinal effects of soft stool and flatulence are usually overcome by reducing he dose. If you find that these nutraceuticals are helping to improve your dog's quality of life, discuss their use with your veterinarian to make sure that they are the best choice for her. For more information about arthritis in your pet you may want to read "Arthritis Cure Eludes Animals and Owners" on our Web site at http://www.vetcentric.com.

08/19/05